Hypersensitivity I, II, III, IV and V

Hypersensitivity definition

• undesirable reactions produced by the normal immune system

Hypersensitivity Type I

• Allergy (immediate)
• IgE

Hypersensitivity Type II

• Cytotoxic, antibody-dependent
• Bind to cell surface components
• and to cell receptors (if you do not use Hypersensitivity Type V classification)
• IgM or IgG
• Complement

Hypersensitivity Type III

• Immune complex disease
• IgG
• Complement

Hypersensitivity Type IV

• Delayed-type hypersensitivity, Cell-mediated immune memory response, antibody-independent
• T-cells

Hypersensitivity Type V

• *Additional, some do not use this classification and combine it with Hypersensitivity Type II
• Cytotoxic, antibody-dependent
• Bind to cell receptors
• IgM or IgG
• Complement